Application of diffusion tensor imaging FA value and ADC value in glioma grading:A Meta-analysis
10.13481/j.1671-587x.20170219
- VernacularTitle:弥散张量成像的部分各项异性值和表观弥散系数值在胶质瘤分级中应用的Meta分析
- Author:
Ruizhe HOU
;
Yingjia ZHAO
;
Yan LIU
;
Qunbang CHEN
;
Hong FU
;
Jingyan CHEN
;
Xingli ZHAO
- Keywords:
diffusion tensor imaging;
glioma;
fractional anisotropy;
apparent diffusion coefficient
- From:
Journal of Jilin University(Medicine Edition)
2017;43(2):311-316
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the significance of the fractional anisotropy(FA) value and apparent diffusion coefficient(ADC) value of diffusion tensor imaging(DTI) applied in the glioma grading with Meta-analysis, and to provide a reference for selecting the treatment program and judging the prognosis of glioma.Methods:Computer search was performed in PubMed database, EMBASE database,CBM, CNKI, Wanfang database, and VIP database.The relevant neurosurgery magazines and neuroimaging magazines, the proceedings of academic meeting were retrieved by hand and the references of related reviews were retrospectively retrieved.Then the case-series studies according to inclusion and exclusion criteria were screened,and the qualities of included studies were evaluated.Meta-analysis was carried out by Review Manager 5.2 software.Results:Nine studies were included.The FA value of low-grade glioma(LGG) in tumor centre was lower than that of high-grade glioma(HGG) (χ2=11.94,df=8,P=0.15;I2=33%,Z=2.78,P=0.005;WMDFA=-0.02,95%CI:-0.03--0.01),and the ADC value of LGG in tumor centre was higher than that of HGG (χ2=5.26,df=4,P=0.26;I2=24%,Z=2.19,P=0.03;WMDADC=0.15,95%CI:0.02-0.28).Conclusion:When the FA value in tumor centre of the glioma is increasd,the ADC value is decreased,and the grade of glioma is increasd.The FA value and ADC value of DTI can help determine the grade of gliomas.
