Virulence and pathogenicity of Toxoplasma gondii ToxoDB# 17 strain oocysts in Kunming mice
10.3969/j.issn.1002-2694.2017.01.009
- VernacularTitle:ToxoDB#17型弓形虫卵囊对昆明小鼠致病性的研究
- Author:
Kai WANG
;
Yongjie FENG
;
Xiaoying FU
;
Yaoyao LU
;
Hongde LIANG
;
Yurong YANG
- Keywords:
ToxoDB# 17;
Toxoplasma gondii;
Kunming mice;
tissue cysts;
pathogenicity
- From:
Chinese Journal of Zoonoses
2017;33(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the pathogenic characteristic of ToxoDB # 17 Toxoplasma gondii in Kunming mice,the mice were fed with ＜1,1,101,102,103,104,105,106 oocysts,and the clinical symptoms of mice were observed.MAT,HE and IHC were used to research the infection rate of T.gondii,survival rate of mice and the number of cysts in brain.The results showed that the mice fed with ≥104 oocysts appeared transient depression,mice were arched,messy hair after infection.The mice fed with ≥102 oocysts were all infected,T.gondii cysts formation rate was 2.38％ (1/42),the survival rate of infected mice was 85.71％ (36/42),the survival time was greater than 360 days.In conclusion,the pathogenicity of ToxoDB# 17 T.gondii is weak,and cysts formation rate is also low.
