Advance in Herpesvirus US10 gene and its encoded protein
10.3969/j.issn.1002-2694.2017.01.012
- VernacularTitle:疱疹病毒US10基因及其编码蛋白研究进展
- Author:
Daixi ZHANG
;
Anchun CHENG
;
Mingshu WANG
- Keywords:
Herpesvirus;
US10 gene;
US10 protein;
immune evasion
- From:
Chinese Journal of Zoonoses
2017;33(1):61-66
- CountryChina
- Language:Chinese
-
Abstract:
US10 gene of Herpesvirus is located in the short unique region of its genome and not essential for virus replication.US10 gene encodes a phosphorylated tegument-capsid associated protein or type Ⅰ transmembrane glycoprotein which selectively targets the cytoplasmic tail of HLA-G,a kind of nonclassical class Ⅰ MHC molecular,to reduce and block the host NK cell cytotoxicity in immune evasion.US10 can also interact with host proteins to play a pathogenic role and regulate the expression of other viral proteins such as glycoprotein E (gE).Through further research,the role of US10 in virulence and its ability to combine with RNA and regulate transcription can be judged in the future.
