Mechanism of Involvement of Intestinal Microbiota in Pathogenesis of Irritable Bowel Syndrome
10.3969/j.issn.1008-7125.2017.03.012
- VernacularTitle:肠道微生态参与肠易激综合征发病的相关机制
- Author:
Xiaojun ZHUANG
;
Minhu CHEN
;
Lishou XIONG
- Keywords:
Irritable Bowel Syndrome;
Intestinal Microbiota;
Permeability;
Immunity;
Gastrointestinal Motility;
Microbe-Gut-Brain Axis
- From:
Chinese Journal of Gastroenterology
2017;22(3):181-183
- CountryChina
- Language:Chinese
-
Abstract:
The etiology and pathogenesis of irritable bowel syndrome (IBS) are not fully understood, and intestinal microbiota had been assumed as a possible factor in the pathogenesis of IBS.Increasing evidences have shown that alterations of gut microbiota were found in IBS patients and modulation of intestinal microbiota might be effective in the treatment of IBS.This article reviewed the mechanism of involvement of intestinal microbiota in pathogenesis of IBS by altering mucosal permeability, activating immune reaction, disturbing gastrointestinal motility and affecting brain-gut axis.
