Research progress in exosomes in tissue fibrosis
10.3867/j.issn.1000-3002.2017.03.010
- VernacularTitle:外泌体对组织纤维化调节作用的研究进展
- Author:
Zhijian RAO
;
Yun CHANG
;
Shiqiang WANG
- Keywords:
exosomes;
tissue fibrosis;
microRNA;
stem cells
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(3):262-268
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are extracellular nanovesicles secreted by a variety of cell types such as cardiomyocyte, hepatocytes, and stem cells. They carry specific sets of mRNA, microRNA, and proteins, which play a role in intercellular communication in almost each physiological and pathological process. Exosomes, which are released after tissue cell injury, can initiate repair/regeneration responses by triggering inflammation and active fibroblast, and finally lead to tissue fibrosis. However, exosomes released by stem cells can retard tissue fibrosis by enhancing cell survival and reducing apoptosis. In this paper, we reviewed the research progress in the relationship between exosomes and tissue fibrosis.
