Refractory Gastroesophageal Reflux Symptoms Not Necessarily Denotes Gastroesophageal Reflux Disease
10.3969/j.issn.1008-7125.2017.03.001
- VernacularTitle:难治性胃食管反流症状一定是胃食管反流病吗?
- Author:
Bin Lü
- Keywords:
Gastroesophageal Reflux;
Esophageal pH Monitoring;
Gastroparesis;
Esophagitis
- From:
Chinese Journal of Gastroenterology
2017;22(3):129-132
- CountryChina
- Language:Chinese
-
Abstract:
The symptoms of gastroesophageal reflux may be induced by acid reflux, nonacidic or weakly acidic reflux, and also can occur with hypersensitive esophagus, esophageal motility disorders, or other organic/anatomical abnormalities of esophagus.Refractory gastroesophageal reflux disease (GERD) denotes the symptoms of GERD could not be remitted with the standard dosage proton pump inhibitor (PPI) therapy.In most patients with refractory symptoms the etiology is of non-reflux-related causes, such as eosinophilic esophagitis, esophageal motility disorders, gastroparesis, or concomitant functional gastrointestinal disorders.A careful and detailed understanding of patient's medical history, examination with endoscopy and biopsy pathology, and esophageal pH-impedance monitoring are very important for identifying the potential cause.
