The biological mechanisms of anhedonia in depression
10.3760/cma.j.issn.1674?6554.2017.03.019
- VernacularTitle:抑郁症快感缺失的生物学机制
- Author:
Weili WU
;
Xinxue GAO
;
Gongying LI
- Keywords:
Depression;
Anhedonia;
Biological mechanisms
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2017;26(3):284-288
- CountryChina
- Language:Chinese
-
Abstract:
Anhedonia is the loss of pleasure or lack of reaction to pleasurable stimuli, which is a promising phenotype of depression. In order to explore the potential biological mechanism, the recent ad?vances were summarized from researches focused on depression with anhedonia from neuroanatomy,inflamma?tion and immunology,and molecular genetics. The structural and functional brain imaging showed that the ac?tivity in reward?related brain regions of the depressive disorder with an anhedonia was changed during re?ward?related tasks.In addition,some other genetic studies based on the related neurotransmitter,such as do?pamine, together with the findings from the researches on immunological inflammation, may shed light on finding the potential targets for novel antidepressants,besides the 5?HT.
