Alterations of Whole Brain Networks Degree Centrality in Patients with Primary Insomnia after Acupuncture Therapy:A Voxel-based Resting-state fMRI Research
- VernacularTitle:基于体素的静息态fMRI观察原发性失眠患者针刺治疗后全脑度中心度的改变
- Author:
Xiaoyue XU
;
Shui WANG
;
Ru LU
;
Xiaofen MA
;
Guihua JIANG
;
Shishun FU
;
Wenfeng ZHAN
;
Jin FANG
- Keywords:
resting-state;
functional magnetic resonance imaging;
primary insomnia;
brain′s functional networks;
degree centrality
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(2):296-300
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the value of degree centrality(DC),a novel resting-state fMRI parameter,in voxel-wise whole-brain functional networks analysis in primary insomnia(PI)after acupuncture therapy.[Methods]The resting state fMRI were performed in 29 PI patients and 22 age,education,and sex-matched normal healthy subjects. Analysis of DC map changes between the two patient groups and the control group were performed by two sample t test.(threshold at P<0.05).[Results]Compared with the control group,patients with PI showed significantly reduced DC value in middle temporal gyrus(MTG. R);hippocampus(HIP. B);parahippocampal gyrus(PHG. R);putamen(PUT. R);cuneus(CUN. L).[Conclusions]Changes of DC value occurred in some region of brain in the PI patient groups when compared with the control group. It was indicated that DC ,as a novel resting-state fMRI parameter in the voxel-wise whole-brain functional networks ,might be an appealing alternative approach for further study on pathologic and neuropsychological states of PI.
