Research progress in metabolic targets for cancer therapy
10.3867/j.issn.1000-3002.2017.03.011
- VernacularTitle:肿瘤代谢靶点用于癌症治疗的研究进展
- Author:
Shiyuan WEN
;
Miaomiao JIANG
- Keywords:
tumor metabolism;
aerobic glycolysis;
glutamine
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(3):269-278
- CountryChina
- Language:Chinese
-
Abstract:
Cancer cells can change metabolic pathways, including glycolysis and glutamine metabolism, and produce the raw materials needed for rapid proliferation and survival. Therefore, research on metabolic pathways of cancer cells might help find the targets of cancer therapy. In this review, we outlined the metabolic features of aerobic glycolysis, glutamine metabolism and (tricarboxylic acid) TCA cycle in cancer. We also described metabolic targets for cancer therapy and therapeutic agents for the corresponding targets in these metabolic pathways, and finally discussed some of the challenges related to tumor metabolism as a therapeutic target in cancer therapy.
