The relationship between LDL-C and ischemic stroke in 2 470 patients with nonvalvular atrial fibrillation in Xinjiang region
10.3760/cma.j.issn.0578-1426.2017.04.004
- VernacularTitle:新疆地区2470例非瓣膜性心房颤动患者低密度脂蛋白胆固醇与缺血性卒中的关系
- Author:
Min WU
;
Xianhui ZHOU
;
Baolatejiang RUOZHA
;
Shifei SONG
;
Yaodong LI
;
Jianghua ZHANG
;
Qiang XING
;
Yanmei LU
;
Baopeng TANG
- Keywords:
Atrial fibrillation;
Low density lipoprotein cholesterol;
Stroke
- From:
Chinese Journal of Internal Medicine
2017;56(4):258-262
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between LDL-C and ischemic stroke in patients with nonvalvular atrial fibrillation (AF).Method A total of 2 470 patients with nonvalvular AF were included in the present study.The clinical data and laboratory examination results of the patients in the hospital were collected.The subjects were either divided into the ischemic stroke history (n =560),and non-ischemic stroke history groups (n =1 910),or divided into the low-middle risk (n =566) and high risk groups (n =1 904) based on CHA2 DS2-VASc score.Results There were significant differences in the proportion of Han,the ratio of gender,age,hemoglobin,hematocrit,ALT,serum uric acid,HDL-C and LDL-C between the patients with ischemic stroke history and without (all P ＜ 0.05).Similarly,there were significant differences in the proportion of Han,the ratio of gender,age,white blood cell count,hemoglobin,hematocrit,platelet count,ALT,albumin,TG and LDL-C between subjects in the low-middle risk group and those in the high risk group (all P ＜ 0.05).A logistical regression analysis showed that LDL-C was an independent risk factor for both the ischemic stroke history (OR 2.089,95％ CI 1.860-2.347,P ＜0.05),and future ischemic stroke risk (OR 1.270,95％ CI 1.079-1.494,P ＜ 0.05) in patients with nonvalvular AF.Conclusion LDL-C is associated with ischemic stroke in patients with nonvalvular AF,and it is also an independent risk factor for future ischemic stroke in these patients.
