Research Progress on Biological Characteristics and Function of Volume Regulated Cl-Channel in Vascular Smooth Muscle Cells
- VernacularTitle:血管平滑肌细胞的容积调节Cl-通道生物学特性及功能研究进展
- Author:
Yongyuan GUAN
- Keywords:
vascular smooth muscle cell;
volume regulated chloride channel;
ClC-3;
LRRC8A;
Bestrophin;
cerebrovascular remodeling;
cell proliferation;
apoptosis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(2):177-183
- CountryChina
- Language:Chinese
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Abstract:
Volume regulated chloride channel (VRCC) enhances cell proliferation through PI3K/Akt signal pathway ,and inhibits cell apoptosis through mitochondrial pathway in vascular smooth muscle cells ,and accelerates the process of atherosclerosis through JNK/p38 MAPK signal pathway,resulting in increasing SR-A expression and ox-LDL uptake. Cerebrovascular remodeling is mediated by VRCC. This effect of VRCC on remodeling is related to accelerating cell proliferation ,migration and accumulation of. extracellular matrix. As to the molecular identification of VRCC ,it is very complex. VRCC is diversity in various cells or tissues , rather than a single ubiquitous channel,VRCC may be contain variedcell type-or tissue-specific subunitcompositions. ClC-3 volume regulated Cl-channel is regulated by both integrin-Src and Rho/RhA-Rock signal pathways.
