Inhibition of Tumor Angiogenesis by Targeted Induction of Endothelial Cell Apoptosis
- VernacularTitle:靶向诱导内皮细胞凋亡抑制肿瘤血管新生的研究进展
- Author:
Xia YANG
- Keywords:
tumor;
angiogenesis;
endothelial cell apoptosis;
K5;
PEDF;
KBP
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2017;38(2):204-214
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is one of the important pathological characteristics in the development of tumor growth. Hence ,an?ti-angiogenes is has become a hot topic in the field of cancer research. The current strategy for anti-angiogenesis therapy is to restore the angiogenic balance which is broken in the tumor via either block of proangiogenic factorsor application of angiogenic inhibitors. Endogenous angiogenic inhibitors show more promising prospects compared with proangiogenic factor antagonists. However ,the un?derlying mechanisms for the angiogenic inhibitors remain to be thoroughly elucidated. There are two kinds of endogenous angiogenic inhibitors,one is the hydrolyzed fragments of precursor protein,such as plasminogen Kringle 5(K5),angiostatin/kringle 1~4,end?ostatin,etc;the other is cell secreted proteins,such as pigment epithelium-derived factor(PEDF),kallikrein-binding protein (KBP/kallistatin),antithrombin,etc. Here we summarized the research progresses on the biological functions,underlying mecha?nisms of tumor angiogenesis and application prospects of K5,PEDF,and KBP,so as to provide insights into the antiangiogenic ther?apies of tumor in the future.
