Clinical analysis of thrombolytic therapy with ischemic in-hospital stroke

VernacularTitle:缺血性院内卒中患者的溶栓疗效分析
Author: Bingjie HE ; Danxia CHEN ; Yunyu CHEN ; Hongchen MAI ; Dawei DONG ; Wanyong YANG ; Anding XU ; Jinsheng ZENG ; Yusheng ZHANG
Keywords: In-hospital stroke; Thrombolysis; Prognosis
From: Chinese Journal of Nervous and Mental Diseases 2017;43(1):4-7
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical effects of thrombolytic therapy in patients with ischemic in-hos-pital stroke (IHS). Methods The clinical data were collected from patients with ischemic IHS in the last five years. The patients were divided into thrombolysis group and non-thrombolysis group, according to the use of recombinant tissue plasminogen activator (r-tPA) treatment. The clinical outcomes were measured by the modified Rankin scale (mRS) at discharge. Results There were a total of 121 patients in this study. There were 6 patients in thrombolysis group and 115 patients in the non-thrombolysis group, respectively. Six patients (100%) in the thrombolysis group achieved favor-able outcomes (mRS 0~2) at discharge whereas only 42 patients (36.5%) in the non-thrombolysis group achieved fa-vourable outcomes. The rate of favorable outcomes was significantly higher in the thrombolysis group than in the non-thrombolysis group (P<0.05). Conclusions R-tPA thrombolytic therapy can improve the prognosis of patients with ischemic IHS.