Expression of FABP5 and its clinic pathological significance in oligodendroglioma
10.13315/j.cnki.cjcep.2016.12.007
- VernacularTitle:少突胶质细胞瘤中FABP5的表达及其临床意义
- Author:
Wanwan GAO
;
Xia ZHAO
;
Gang MENG
;
Li CAI
- Keywords:
brain neoplasms;
oligodendroglioma;
FABP5;
Ki-67;
prognosis;
immunohistochemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2016;32(12):1348-1352
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of FABP5 in oligodendroglioma and its clinic pathological significance.Methods Immunostaining of FABP5 and Ki-67 were performed in 87 oligodendrogliomas and 23 paracancerous brain tissues.The relationships between FABP5 expression and Ki-67 expression or clinic pathological parameters were statistically analyzed.Patients were followed up after operation.Results (1) The expression of FABP5 was significantly higher in oligodendroglioma [63.2％ (55/87)] than that in normal control [34.8％ (8/23)].(2)The expression of FABP5 was positively correlated with the histological grade (P =0.018,rs =0.254) and the Ki-67 expression (P =0.003,rs =0.318) in oligodendroglioma.(3) Univariate analysis showed that the expression of FABP5 protein,Ki-67 protein,age and chemotherapy were significant prognostic factors for oligodendroglioma patients.Conclusion FABP5 may play an important role in the pathogenesis and progression of oligodendroglioma,and could be used as a novel biological indicator of disease progress as well as prognosis for oligodendroglioma patients.
