Expression of miR-21 in prostate cancer and its clinical significance
10.13315/j.cnki.cjcep.2016.12.011
- VernacularTitle:前列腺癌组织中miR-21的表达及临床意义
- Author:
Cong ZHANG
;
Liyu CAO
;
Yu YIN
;
Shunhua CHEN
;
Yujie LI
- Keywords:
prostate neoplasm;
benign prostatic hyperplasia;
miR-21;
in situ hybridization
- From:
Chinese Journal of Clinical and Experimental Pathology
2016;32(12):1365-1367
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression and clinical significance of microRNA-21 (miR-21) in patients with prostate cancer (PCa).Methods The human tissue specimens were paraffin-embedded blocks which were collected from the Department of Pathology.miR-21 was detected by in situ hybridization (ISH) in 90 cases of PCa and 69 cases of benign prostatic hyperplasia (BPH).Results The ISH data showed that the positive rate of miR-21 in PCa (71.1％) was significantly higher than that in BPH (24.6％) (P ＜ 0.05),the expression of miR-21 correlated with the Gleason grade (P ＜ 0.05),and no relationship was observed with other clinicpathological features (P ＞ 0.05).Conclusion The miR-21 plays an important role in the pathogenesis of PCa,which can be a new diagnostic target for PCa.
