Henoch-Sch(o)nlein purpura nephritis in children: an update on the diagnosis and treatment
10.3760/cma.j.issn.2095-428X.2017.05.002
- VernacularTitle:儿童紫癜性肾炎诊治进展
- Author:
Aihua ZHANG
;
Chunhua ZHU
- Keywords:
Henoch-Sch(o)nlein purpura nephritis;
Child;
Diagnosis;
Treatment
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(5):324-327
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-Sch(o)nlein purpura (HSP) is the common form of systemic vasculitis in children,which characterized by the deposition of immunoglobulin E within the small vessels.The long-term prognosis of HSP depends on the severity of renal involvement.Renal involvement in HSP affects 10％-100％ patients and the clinical manifestations vary from microscopic hematuria to nephritic/nephritic syndrome even renal dysfunction.Early diagnosis,early treatment and long-term follow-up affect the prognosis of HSP patients.As for the treatment of HSP nephritis (HSPN),there have been many reports dealing with the immunosuppressive agents.Now glucocorticoid is the first-line treatment for HSPN,and other immunosuppressive agents offer more choices to treat HSPN especially for severe HSPN.But,the use of immunosuppressive agents still needs large sample multicenter randomized controlled trials and evidence-based study.
