Diagnostic significance of plasma total tau and phosphorylated tau protein in Alzheimer's disease
10.3969/j.issn.1673-4130.2017.01.014
- VernacularTitle:血浆总tau蛋白和磷酸化tau蛋白在阿尔茨海默病中的诊断意义
- Author:
Jianhua KANG
;
Lishun YANG
;
Na LI
- Keywords:
alzheimer's disease;
plasma total tau protein;
phosphorylation of tau protein
- From:
International Journal of Laboratory Medicine
2017;38(1):37-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the plasma total tau(T-tau)and phosphorylated protein tau(P-tau)protein in the diagnosis of Alzheimer's disease(AD).Methods 22 352 medical patients aged over 60 years in Beichen Area Community Service Center were involved in this survey.Random sampling principle was used for screening.Mini-mental state examination(MMSE)and activities of daily living assessment form(ADL)were conducted for the cognitive function and ability of daily score firstly.When the score below the standard,the Hamilton depression scale and Hachinski ischemic scale were re-used for diagnostic score.Related laboratory tests were conducted to exclude other central nervous system and other systems and material causes of dementia patients.Ultimately,105 cases of AD,diagnosed by the neurologist,and 42 cases of non central nervous system disease,non dementia non nervous system disease patients as the normal control group were involved.T-tau and P-tau levels in the two groups were determined by ELISA.Results the T-tau concentration in AD group(15.93+6.59)ng/L was higher than control group(14.10±6.32)ng/L,no significant difference was found (P ＞ 0.05).However,compared with control group (0.69 ± 0.24) ng/L,P-tau protein in AD group (1.26 ± 0.75)ng/L increased significantly(P＜0.05).Conclusion Plasma levels of phosphorylated tau protein might have diagnostic value for AD patients.
