Psychosocial Factors Associated with Biological Markers in Korean Patients with Human Immunodeficiency Virus Infection.
- Author:
Sang Hyuk LEE
1
;
Kyoung Bong KOH
;
June Myung KIM
;
Sung Kwan HONG
;
Tae Kyou CHOI
;
Eun Hee LEE
;
Shin Young SUH
Author Information
1. Department of Psychiatry, College of Medicine, Bundang CHA Hospital, Pochon CHA University, Seongnam, Korea. fishnsea@hanmail.net
- Publication Type:Original Article
- Keywords:
HIV;
Stress;
CD4+ cell count;
Coping strategy
- MeSH:
Aggression;
Biomarkers*;
CD4 Lymphocyte Count;
Depression;
Frustration;
Heterosexuality;
HIV Infections;
HIV*;
Homosexuality;
Humans;
Humans*;
Psychology*;
Quality of Life
- From:Journal of Korean Neuropsychiatric Association
2006;45(1):34-41
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to identify psychosocial factors associated with biological markers in Korean patients with human immunodeficiency virus (HIV) infection. METHODS: 50 patients with HIV infection were enrolled. We administered Stress Response Inventory (SRI), the Coping Scale, and the Korean version of Smithklein Beecham quality of life scale (QOL) to the 50 patients and measured CD4+ cell count and HIVRNA copies. RESULTS: Simple correlation analysis showed significant correlation between psychosocial factors and CD4+ cell count. Tension, aggression, depression, frustration subscale in SRI and distancing, self controlling in coping scale had negative correlation with CD4+ cell count, whereas QOL showed positive correlation. Multiple regression analysis showed significant negative association between distancing and CD4+ cell count. There were no differences in CD4+ cell count and HIVRNA between homosexual patients and heterosexual patients. However, aggression, confrontation in SRI, and distancing in coping scale scored significantly higher in heterosexual patients than homosexual patients. CONCLUSION: These results suggest that CD4+ cell count may be associated with psychosocial factors in Korean patients with HIV infection, and passive coping strategy like distancing may be one of important factors in the progression of HIV infection. These findings also suggest that psychosocial intervention programs are needed for Korean patients with HIV infection.
