The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients
- VernacularTitle:云南汉族原发性高血压ACE基因多态性与厄贝沙坦降压疗效相关性
- Author:
Hong HUANG
;
Bo CHEN
;
Yan LI
;
Shenglin QUAN
;
Linqing TANG
;
Tong ZHANG
;
Jing QUAN
- Keywords:
Yunnan;
Han ethnic;
Essential hypertension;
ACE gene;
Gene polymorphism;
Irbesartan;
Efficacy
- From:
Journal of Kunming Medical University
2016;37(7):40-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlationship of ACE I/D gene polymerphisms with the anti-hypertensive efficacy of irbesartan among essential hypertension (EH) patients in Yunnan han people.Methods One hundred EH patients hypertension were treated with irbesartan 150mg once daily for 4 weeks,and anti-hypertensive efficacy were monitored during the treatment.Results There was a significant difference between anti-hypertensive efficacy of irbesartan among different genotype groups,DD group ＞ID group ＞Ⅱ group (P ＜ 0.05) Conclusions There is different therapy responsiveness in diffenent genotypes.ACE I/D polymorphism may be an important hereditary factor that impacts the efficacy of irbesartan.
