Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation
- VernacularTitle:迷迭香提取物对小鼠脑缺血的保护作用及急性毒性评价
- Author:
Lanchun ZHANG
;
Shangwen WANG
;
Weiyan HU
;
Ronghua ZHAO
;
Haofei YU
;
Rongping ZHANG
- Keywords:
Rosemary' s chloroform extract;
Cerebral ischemia;
Acute toxicity evaluation
- From:
Journal of Kunming Medical University
2016;37(12):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective effects of Rosemary's chloroform extract on cerebral ischemia in mice and acute toxicity.Methods The protective of rosemary's chloroform extract on cerebral ischemia was observed and compared by the mice models of cerebral anoxia and ischemia,thrombus formation in vivo,and chloroform induced arrhythmias.Rosemary's Chloroform Extract was given orally to mice to evaluate acute toxicity.Results Rosemary's chloroform extract had different degrees of inhibition of collagen-the adrenaline induced thrombus formation,and prolonged acute ischemic mice brains off mouth breathing time and increase the number of mouth breathing (P ＜0.05 or P ＜0.01);Chloroform extract significantly reduced the incidence of chloroform induced ventricular arrhythmias.Acute toxicity results suggested that a female rat died in the next day of chloroform extract group,no additional toxicity was observed.Conclusion Rosemary's chloroforrm extract has significant protective effect on cerebral ischemia and hypoxia in mice.
