Study of CJ016 in treatment of lung cancer
10.3969/j.issn.1001-1978.2017.03.018
- VernacularTitle:CJ016对人肺癌裸鼠移植瘤的抑制活性研究
- Author:
Ping GAN
;
Yonghong TAN
;
Weihua JIN
;
Lingjie WANG
;
Botao YU
- Keywords:
lung cancer;
mechanism;
CJ016;
A549;
IC50;
CD31;
apoptosis
- From:
Chinese Pharmacological Bulletin
2017;33(3):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Aim Tostudythetherapeuticeffectof CJ016 on human lung cancer model and the mecha-nism.Methods Anexperimentalhumanlungadeno-carcinoma model of A549 was set up to investigate the anti-tumor effect of CJ016,while the effect of angio-genesis and apoptosis in tumor were detected.Results In vitro,the cell proliferation was inhibited signifi-cantly by CJ016,and the value of IC50 was 34. 22 nmol ·L-1 .In vivo,the tumor inhibition rate and T/C%value were 70. 08%and 27. 75%,respectively,at the dose of 20 mg·kg-1 .Meanwhile,CJ016 could reduce the expression of CD31 and promote the apoptosis of tumorcells.Conclusion CJ016caninhibitthegrowth of A549 cells,and the possible mechanism may be re-lated to the reduction of angiogenesis and inducing tumor cell apoptosis.
