Progress in the role of Wip1
10.3969/j.issn.1000-4718.2017.03.031
- VernacularTitle:Wip1相关研究进展
- Author:
Kemei LIU
;
Hongbing YAN
- Keywords:
Wip1;
Tumor;
Senescence;
Immune;
Inflammation;
Metabolism
- From:
Chinese Journal of Pathophysiology
2017;33(3):562-566
- CountryChina
- Language:Chinese
-
Abstract:
Wildtype p53-induced phosphatase 1 (Wip1) is a serine/threonine protein phosphatase of 605 ami-no acids, which is expressed at high levels in many organs and tissues .As Wip1 is overexpressed in human tumors , analy-sis of Wip1 has focused primarily on its role in tumorigenesis .In recent years , it has also been shown that Wip 1 plays an important role in several physiological processes including adult neurogenesis , senescence , immunodeficiency and metabolic diseases.This review addresses how Wip1 participates in physiological and pathological conditions at cellular and molecular levels.
