Progress in occurrence and development of ferroptosis
10.3969/j.issn.1000-4718.2017.03.032
- VernacularTitle:细胞铁死亡发生与调控机制的研究进展
- Author:
Chuanjie KANG
;
Xiangtong ZHANG
;
Wei MA
- Keywords:
Cell death;
Ferroptosis;
Iron;
Lipids;
Reactive oxygen species
- From:
Chinese Journal of Pathophysiology
2017;33(3):567-571
- CountryChina
- Language:Chinese
-
Abstract:
With the development of modern medical research , it has been found that there are many forms of cell death under lots of physiological or pathological conditions .Among them, necrosis and apoptosis are the 2 main forms of cell death.In recent years, varieties of new cell death patterns, such as autophagy, oncosis and paraptosis, have been discovered.In 2012, Dixon et al first discovered and reported a new form of iron-dependent cell death , ferroptosis.In this review, we try to expound the morphological and biochemical features of ferroptosis and its related diseases in detail , so as to deepen our understanding of cell death , thus providing new ideas for the prevention and treatment of clinically relevant diseases .
