Simvastatin regulates endogenous stem cells to reconstruct the degenerative intervertebral disc
10.3969/j.issn.2095-4344.2017.05.025
- VernacularTitle:辛伐他汀调控内源性干细胞进行退变椎间盘的内源性修复和重建
- Author:
Zenan HUANG
;
Xinmin FENG
;
Jingcheng WANG
;
Tao CHEN
;
Songchao BI
;
Liang ZHANG
- From:
Chinese Journal of Tissue Engineering Research
2017;38(5):809-814
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Statins can promote the mRNA expression of bone morphogenetic protein 2, aggrecan and type II col agen in intervertebral disc cel s, and they also can reverse the phenotype of dedifferentiated nucleus pulposus cel s to slow disc degeneration process. OBJECTIVE:To review the research progress of simvastatin modulating the biological characteristics and mobilizing endogenous stem cel s for the repair of intervertebral disc degeneration. METHODS:The first author retrieved the PubMed and CNKI databases for relevant articles published before January 2016 using the key words of“disc degeneration factor, Simvastatin AND stem cel s, endogenous stem cel s AND disc degeneration”in English and Chinese, respectively. Initial y, 102 relevant articles were retrieved, but only 48 articles were included in result analysis fol owing elimination of duplicate studies.RESULTS AND CONCLUSION:By summarizing a large number of studies on the treatment of intervertebral disc degeneration worldwide, we found that simvastatin may modulate the biological characteristics and function of nucleus pulposus mesenchymal stem cel s via promoting the expression of hypoxia-inducible factor 1αfor the endogenous stem cel-based therapy of intervertebral disc degeneration.
