Research on preventative role of Nrf2 in kidney diseases
10.3969/j.issn.1001-1978.2017.03.002
- VernacularTitle:以Nrf2为靶点防治肾脏疾病的研究进展
- Author:
Sisi CAO
;
Miao YAN
;
Bikui ZHANG
;
Yunsheng JIANG
;
Xinrong FAN
- Keywords:
Nrf2;
oxidative stress;
NF-κB;
renal ischemia-reperfusion injury;
acute kidney injury;
chronic kidney disease
- From:
Chinese Pharmacological Bulletin
2017;33(3):301-305
- CountryChina
- Language:Chinese
-
Abstract:
Nrf2,a key transcriptional factor in regulating endog-enous antioxidant signaling pathway,maintains the redox bal-ance by controlling the expression of a battery of antioxidant en-zymes,phase-Ⅱ detoxification enzymes and phase-Ⅲ transport-ers.Furthermore,Nrf2 regulates inflammation.Recent resear-ches have confirmed that Nrf2 provides a vital physiological role in kidney diseases,activation of Nrf2 enhances the antioxidant and anti-inflammatory ability in cellular and tissue levels,thusalleviates renal injury.Here,this article aims to summarize the protective effect of Nrf2 on various models of kidney impairment and explore the potential of Nrf2 as a therapeutic target to pre-vent kidney diseases.
