Advances in bacterial extracellular metalloproteases and their pathogenic roles
10.3760/cma.j.issn.0254-5101.2017.02.013
- VernacularTitle:细菌胞外金属蛋白酶及其致病作用的研究进展
- Author:
Yingying ZHANG
;
Jie YAN
;
Yumei GE
- Keywords:
Bacteria;
Metalloproteases;
Structure;
Function;
Pathogenic role
- From:
Chinese Journal of Microbiology and Immunology
2017;37(2):161-164
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial extracellular metalloproteases ( BEMPs) are a large group of metal ion-contai-ning proteases. All BEMPs identified so far are endopeptidase or endoprotease. BEMPs can be classified into nine metalloprotease families based on the sequences and structures of enzymatic molecules. Double-valence zinc ion ( Zn2+) is necessarily required by catalytic centers of most BEMPs. The main function of BEMPs in non-pathogenic heterotrophic bacteria is to hydrolyze environmental proteins and polypeptides to provide vari-ous amino acids as nutrients. However, BEMPs of pathogenic bacteria, serving as important virulence fac-tors, help the pathogens invade into hosts and spread in hosts. In recent years, the roles and mechanism of BEMPs in bacterial pathogenesis have attracted great attention. Here, we make a brief review about the structures and types as well as the functions and pathogenic roles of BEMPs.
