Combined detetion of SCC ,CEA and CA125 in early diagnosis of lung cancer by chemiluminescence
10.3969/j.issn.1673-4130.2017.05.014
- VernacularTitle:SCC、CEA、CA125化学发光法联合检测在肺癌早期诊断中的价值
- Author:
Zhenhua TAN
;
Yueying WANG
;
Zihui LIAO
;
Haizhu LI
- Keywords:
SCC;
CEA;
CA125;
lung cancer;
sensitivity
- From:
International Journal of Laboratory Medicine
2017;38(5):611-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical application effect of squamous cell carcinoma antigen (SCC) ,cancer embryo antigen (CEA) and carbohydrate antigen 125(CA125) chemiluminescence combined detection in early diagnosis of lung cancer .Methods The SCC ,CEA and CA125 levels in the patients with early stage lung cancer ,benign lung diseases and healthy subjects undergoing physical examination were detected by using the automatic chemiluminescence immune analyzer .Results The concentrations of three tumor markers in the lung cancer group were significantly higher than those in the benign disease group and control group (P<0 .05);t he concentrations of CEA and CA125 in the adenocarcinoma patients with were significantly higher than those in the patients with squamous cell carcinoma and small cell carcinoma (P<0 .05) .The concentration of SCC in the patients with squamous cell carcinoma was significantly higher than that in the patients with adenocarcinoma and small cell lung cancer (P<0 .05) .The sen-sitivity ,specificity ,positive predictive value and negative predictive value of combined detection of three tumor markers were signifi-cantly better than that of single tumor marker ,and the difference was statistically significant (P<0 .05) .Conclusion The combined detection of SCC ,CEA and CA125 can be used in the early diagnosis of lung cancer and has the promotion value .
