Progress in the research of epigenetic regulation of airway smooth muscle cells in asthma
- VernacularTitle:哮喘气道平滑肌细胞表观遗传学调控的研究进展
- Author:
Xin Lü
;
Biwen MO
- Keywords:
asthma;
airway smooth muscle cell;
epigenetics
- From:
Basic & Clinical Medicine
2017;37(3):419-421
- CountryChina
- Language:Chinese
-
Abstract:
Hyperplasia of smooth muscle cells is a major aspect of airway remodeling in asthma .In recent years.It is found that the epigenetic regulation plays an important role on the proliferation of airway smooth muscle cells and the secretion of inflammatory cytokines , including DNA methyltransferase inhibitors to inhibit the phenotype trans-formation;histone acetylation related with hypertrophy .In addition , the microRNA is potentially related with the regulation of a variety of physiological functions of airway smooth muscle cells of asthma model , including inhibition of proliferation and release of inflammatory factors .Hope that epigenetics can become a new target for the treatment of asthma .
