Research progress in mechanisms of opioids-induced respiratory depression
- VernacularTitle:阿片类药物呼吸抑制作用的机制研究进展
- Author:
Xiaowen LIU
;
Zhen LIU
;
Jing ZHAO
- Keywords:
opioids;
opioid receptors;
respiratory depression
- From:
Basic & Clinical Medicine
2017;37(3):422-426
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory depression is a common adverse effect of opioids .Currently, the mechanisms and manage-ment of opioid-induced respiratory depression ( OIRD) are one of the research foci .OIRD arises from stimulation ofμ-opioid receptors in the pre-Botzinger complex and the Kolliker-Fuse neurons .Adenylyl cyclase , calcium chan-nels, and G-protein-gated inwardly rectifying potassium (GIRK) channels may be the key cellular signaling mecha-nisms of OIRD .
