Expression and clinical significance of PD-L2 molecule on monocytes of peripher-al blood in systemic lupus erythematosus

VernacularTitle:系统性红斑狼疮患者外周血单核细胞PD-L2分子的表达及其临床意义
Author: Pingping WU ; Dong SHEN ; Yundi GUO ; Yaqin ZHANG ; Fengqing FU ; Cuiping LIU ; Jing SUN
Keywords: Systemic lupus erythematosus; PD-L2; SLEDAI
From: Chinese Journal of Immunology 2017;33(3):414-417
CountryChina
Language:Chinese
Abstract: Objective:To analyze PD-L2 expression on monocytes of peripheral blood cells in systemic lupus erythematosus ( SLE) and it′s correlation with the degree of disease activity .Methods:Peripheral blood of 26 cases of SLE patiens and 38 cases of healthy controls were collected .Peripheral blood mononuclear cells ( PBMC) were isolated and realtime PCR was carried on to analyze the PD-L2 gene expression.At the same time flow cytometry was performed to analyze the CD 14 and PD-L2 expression.Results:PD-L2 was significantly up-regulated on monocytes in RA patients than in healthy controls and had correlation with the disease activity and the SLEAI score.Conclusion:These findings help to clarify the function of PD-L2,including its potential role as a biomarker for SLE .