Expression and clinical significance of serum IL-37 and soluble PD-1 in patients with rheumatoid arthritis
10.3969/j.issn.1000-484X.2017.03.022
- VernacularTitle:类风湿关节炎患者血清IL-37和可溶性PD-1分子的表达水平及临床意义
- Author:
Xixi CHEN
;
Juan TIAN
;
Jing ZHANG
;
Jiang SU
- Keywords:
Rheumatoid arthritis;
Interleukin-37;
Soluble PD-1;
Cytokines
- From:
Chinese Journal of Immunology
2017;33(3):422-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between IL-37 and soluble PD-1 in patients with rheumatoid arthritis ( RA) , and investigate the relationship between IL-37 and soluble PD-1.Methods: Peripheral blood was collected from RA patients and control group.The levels of IL-37 and sPD-1 in 30 RA patients (RA standard score ≥6) and 30 healthy controls were measured by enzyme-linked immunosorbent assay ( ELISA).The expression of IL-18, IL-6 and IL-18BP in the peripheral blood of two groups was analyzed and the correlation was analyzed by Pearson correlation analysis .Results:The results of ELISA detection showed that the ex-pression levels of IL-37 and sPD-1 in the peripheral blood of patients with RA and other inflammatory cytokines such as IL -18, IL-18BP and IL-6 were higher than those of healthy controls (P<0.05).IL-37 was positively correlated with cytokines IL-18, IL-18BP and IL-6;sPD-1 was positively correlated with cytokine IL-6.IL-37 and sPD-1 were positively correlated with the severity of patients.Conclusion:IL-37 and sPD-1 are elevated in RA patients and associated with other inflammatory cytokines and disease severi -ty.Both of them may play an important regulatory role in the progress of RA , and provide a new basis for future RA therapy .
