The potential therapeutic effects of glucagon like peptide-1 receptor agonists in patients with diabetes mellitus induced erectile dysfunction

VernacularTitle:胰高血糖素样肽-1受体激动剂在糖尿病性勃起功能障碍患者中的潜在治疗作用
Author: Fengjiao DONG ; Lihong WANG ; Hui CHE ; Meihua LIANG ; Xuelian FU
Keywords: Erectile dysfunction; Glucagon-like peptide 1; Diabetes mellitus; Review
From: Chinese Journal of Postgraduates of Medicine 2017;40(3):282-285
CountryChina
Language:Chinese
Abstract: Diabetic mellitus induced erectile dysfunction (DIED) is a common complication of type 2 diabetes mellitus (T2DM), which seriously affects the physical and mental health of male T2DM patients. The occurrence of DIED involves a variety of pathophysiological changes such as vascular tissue, nerve, endocrine and so on. But the traditional treatment of erectile dysfunction is not ideal for DIED. Glucagon like peptide (GLP)- 1 receptor agonist has been widely used as a new drug for the treatment of diabetes, and the representative drugs are exenatide and liraglutide. Existing research shows that it can improve endothelial cell function, neuropathy and sex hormone secretion, reduce body weight and insulin resistance. Therefore, these drugs may be a new choice for patients with DIED.