Challenge and present status of fecal microbiota transplantation in the treatment of ulcerative colitis

VernacularTitle:粪菌移植治疗溃疡性结肠炎的现状和挑战
Author: Lulu HU ; Binbin WANG ; Fangxin ZHANG
Keywords: Colitis; ulcerative; Fecal microbiota transplantation; Review
From: Chinese Journal of Postgraduates of Medicine 2017;40(3):285-288
CountryChina
Language:Chinese
Abstract: Ulcerative colitis (UC) is a subtype of inflammatory bowel disease. Its pathogenesis is not clear and the pathogenesis is complex. Moreover, it is recurrent and its healing is delayed. It is a kind of refractory disease. Its incidence and recurrence rate showed a trend of increasing year by year in our country at present. At the present stage, the main treatment focuses on glucocorticoids, aminosalicylic acid, immunosuppressor and biological agent. Although biological agent can greatly improve the efficacy, there are many problems in clinical treatment for a small amount of refractory patients. The comprehensive intervention combined with non-drug treatment should be performed, so as to achieve the curative effect. Fecal microbiota transplantation (FMT) has attracted people′s attention in recent years. It displays a certain therapeutic effect on the treatment of UC in the active stage, especially refractory recurrent UC. Therefore, the domestic and overseas FMT treatment are summarized in the paper.