Preparation and characterization of docetaxel incorporated in phosphatidylcholine-sodium desoxycholate mixed micelles
10.7644/j.issn.1674-9960.2017.01.013
- VernacularTitle:多西他赛磷脂／胆盐复合胶束的制备及性质研究
- Author:
Qiaoqiao HU
;
Guiying FU
;
Junling WANG
;
Xujing SUN
- Keywords:
docetaxel;
phosphatidylcholine;
bile salt;
mixed micelles;
solubility
- From:
Military Medical Sciences
2017;41(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare and characterize docetaxel incorporated phosphatidylcholine -sodium desoxycholate mixed micelles (DOX EPC/SDC MMs).Methods Docetaxel mixed micelles (DOX MMs) were prepared using the co-precipitation method .An optimized formulation was obtained by single factor method , which was used to study the effect of several factors on water solubility of DOX in MMs, including EPC/total(EPC+SDC)concentration, total(EPC+SDC) concentration, the pH and ionic strength of the hydrated solution .Then, the obtained DOX MMs were characterized by investigating particle size distribution and morphology , and by conducting dilute experiments to examin micelle stability . Results The EPC/total ( EPC+SDC) concentration ratio was 0.4.The total supplementary material concentration was 2.5%.Pure water was used to disperse the film .The drug loaded MMs had an average size of 18.56 nm and average zeta potential of -24.3 mV.A roundlike shape was observed under a transmission electron microscope ( TEM).Conclusion DOX EPC/SDC MMs, prepared by a simple and convenient method , can enhance water solubility , is physically compatible with injection solutions and is expected to become a new drug delivery system .
