Correlation of plasma heme oxygenase-1 level and type 2 diabetes mellitus
10.3969/j.issn.1005-1678.2017.01.083
- VernacularTitle:血浆血红素氧化酶水平与2型糖尿病关系的临床研究
- Author:
Cheng XUE
;
Jiajia ZHAO
;
Yi CHENG
;
Jinyou WU
- Keywords:
heme oxygenase-1;
type 2 diabetes mellitus;
correlation;
clinical study
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):277-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of plasma heme oxygenase-1 (HO-1) level and type 2 diabetes mellitus (T2DM). Methods The outpatient with type 2 diabetes mellitus (T2DM) undergoing oral glucose tolerance test and healthy individuals with physical examination were divided into T2DM group and healthy control group, the differences between the two groups in HO-1 and methane dicarboxylic aldehyde (MDA), mean fluorescence intensity (MFI), homeostasis model assessment of insulin resistance (HOMA-IR) and fasting blood glucose (FBG) were comparatively analysed , and analyzed the correlations between HO-1 and reactive oxygen species (ROS) MFI, MDA, HOMA-IR and FBG. Results The type 2 diabetes group in MDA and MFI, the expression rate of HO-1 were higher than those of control group (P<0.05), correlation analysis of expression of HO-1 was positively correlated with MFI, MDA (r=0.489, 0.763, P<0.05) in the T2DM group, HO-1, HOMA-IR and FBG were significantly higher than the healthy control group, the difference was statistically significant(P<0.05). The expression of HO-1 and HOMA-IR and FPG levels were positively correlated in the T2DM group (r=0.271, 0.426, P <0.05). Conclusion T2DM patients with hyperglycemia and oxidative stress, plasma HO-1 expression is significantly increased, HO-1 is related to oxidative stress, insulin resistance and hyperglycaemia, which has certain value on clinical assessment of T2DM and therapeutic efficacy.
