The correlation study between heart rate variability and atherosclerosis in primary hypertension patients
10.3760/cma.j.issn.1008-6706.2017.05.003
- VernacularTitle:原发性高血压患者心率变异性与动脉硬化的相关性研究
- Author:
Lan YANG
- Keywords:
Hypertension;
Heart Rate;
Arteriosclerosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(5):651-654
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between heart rate variability and atherosclerosis in primary hypertension patients.Methods 282 primary hypertension patients with carotid ultrasound were selected and divided into the arteriosclerosis group (n =201 )and the non -arteriosclerosis group (n =81 )according to the carotid ultrasound examination results.The ambulatory blood pressure and electrocardiogram (ECG)in the two groups were recorded and compared,as well as heart rate variability index.Results Age[(60.2 ±5.2)years]and body mass index [(27.8 ±1.7)kg/m2 ]in the atherosclerosis group were significantly higher than those in the non -arteriosclerosis group[(56.4 ±7.1)years,(26.2 ±2.3)kg/m2 ,t =4.98,6.43,all P <0.05].The course of hypertension in the atherosclerosis group[(11.3 ±1.0)years]was significantly longer than that in the non -arteriosclerosis group[(8.6 ± 1.1)years,t =19.93,P <0.05].In the atherosclerosis group,24h SBP,24h DBP,dSBP,dDBP,nSBP and nDBP were significantly longer than those in the non -atherosclerosis group(t≥6.10,all P <0.05).In the atherosclerosis group, heart rate variability time domain analysis indicators including SDNN,SDANN,SDNN index,RMSSD and PNN50 were (105.7 ±5.1)ms,(96.8 ±12.5)ms,(41.4 ±8.5)ms,(28.5 ±4.7)ms,(10.2 ±3.1)% respectively,which were all significantly lower than those in the non -atherosclerosis group[(127.3 ±4.8)ms,(139.0 ±13.4)ms,(48.2 ± 7.3)ms,(34.9 ±5.0)ms,(13.7 ±4.3)%],the differences were statistically significant(t≥5.76,all P <0.05). Conclusion In primary hypertension patients,heart rate variability has obvious correlation with arteriosclerosis, which heart rate variability is reduced and have low blood pressure regulation,so that the heart rate variability can be used as an important indicator for primary hypertension disease and prognosis judgement.
