The changes of plasma albumin,total bilirubin and serum inflammatory factors,gonadal hormone levels in men with bipolar disorder and the clinical significance
10.3760/cma.j.issn.1008-6706.2017.05.021
- VernacularTitle:双相情感障碍男性患者血浆白蛋白、总胆红素和血清炎性因子、性腺激素水平变化及临床意义
- Author:
Wenyao QI
- Keywords:
Bipolar disorder;
Plasma albumin;
Total bilirubin;
Serum inflammatory factor;
Gonadal hormone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(5):721-724
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe plasma albumin,total bilirubin and serum inflammatory factors,gonadal hormone levels in men with bipolar disorder,and to provide evidence for the diagnosis of the disease.Methods 48 men with bipolar disorder were selected as disease group,and 42 cases of male physical examination were selected as control group.Plasma albumin,total bilirubin and serum inflammatory factors,gonadal hormone levels of the two groups were detected.Results The levels of serum albumin and total bilirubin of the disease group were (43.4 ± 3.9)g/L and (9.4 ±1.9)μmol/L,which were lower than those of the control group[(49.6 ±3.0)g/L and (11.8 ± 2.1)μmol/L],the differences were statistically significant (t =8.361,5.692,all P <0.05).The levels of serum inflammatory factors IL -1 and IL -4 of the disease group were (4.2 ±2.2)ng/L and (3.3 ±1.8)ng/L,which were higher than those of the control group[(1.3 ±1.0)ng/L and (1.6 ±0.9)ng/L],the differences were statistically significant (t =7.858,5.542,all P <0.05).There were no significant differences in the levels of serum LH,PRL, FSH and PRG between the two groups(all P >0.05).The serum level of E2 of the disease group was (23.2 ± 16.1)pg/mL,which was lower than (35.9 ±18.0)pg/mL of the control group,the serum T level of the disease group was (10.8 ±4.9)ng/mL,which was higher than (4.2 ±1.6)ng/mL of the control group,the differences were statistically significant(t =3.533,8.344,all P <0.05).Conclusion Plasma albumin,total bilirubin and serum IL -1β,IL -4 levels can be used as references for clinical diagnosis of bipolar disorder,and serum E2 and T levels can be used as risk factors for bipolar disorder.
