A Case of Richter's Syndrome Showing the Transformation from Chronic Lymphocytic Leukemia to Diffuse Large B - cell Lymphoma.
10.5021/ad.1998.10.4.274
- Author:
Jae Wang KIM
;
Kwang Joong KIM
;
Jong Min KIM
;
Chong Ju LEE
- Publication Type:Case Report
- Keywords:
Richter's syndrome
- MeSH:
Adult;
B-Lymphocytes;
Clone Cells;
Drug Therapy;
Humans;
Hypercalcemia;
Leukemia, Lymphocytic, Chronic, B-Cell*;
Lymphatic Diseases;
Lymphoma*;
Male;
Skin
- From:Annals of Dermatology
1998;10(4):274-280
- CountryRepublic of Korea
- Language:English
-
Abstract:
We herein report a case of Richters syndrome(RS) that was discovered following an investigation of a skin lesion. RS represents an acute transformation of chronic lymphocytic leukemia(CLL) to highly malignant large cell lymphoma such as diffuse large B-cell lymphoma(DLBCL). RS is characterixed by abrupt B-symptoms, rapidly progressive lymphadenopathy, hepatosplenomegaly, frequent extranodal involvement, hypercalcemia and an unfavorable clinical course. The patient is a 31-year-old male with skin lesions on his face. He had been previously diagnosed with CLL. At his presentation, CLL and DLBCL manifestly co-existed. Our multistage analysis suggested that DLBCL and CLL might arise from a different B-cell clone. He showed a poor clinical response to systemic chemotherapy.
