Estrogen receptor negative primary breast carcinoma:correlation of human epidermal growth factor receptor type 2 overexpression with mammography and clinic features
10.3969/j.issn.1002-1671.2017.01.014
- VernacularTitle:ER阴性原发性乳腺癌HER-2过表达与X线表现及临床特征相关分析
- Author:
Shaojun MA
;
Xiaoli KANG
;
Xiaoyan LIANG
;
Wensheng LI
- Keywords:
breast cancer;
estrogen receptor;
epidermal growth factor receptor type 2;
mammography
- From:
Journal of Practical Radiology
2017;33(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of human epidermal growth factor receptor type 2 overexpression (HER-2+)and mammographic and clinical features in breast cancers with estrogen receptor negative expression (ER-).Methods 190 cases of ER-breast cancer were included in this study.There were 78 cases with HER-2+,and 112 cases with HER-2-.The pathological and mammographic features were compared between the two groups.Results Compared with the HER-2- group,the HER-2+ group was more in older women (P<0.001)and more likely to have a lymphonodus metastasis (P=0.011).For mammographic manifesta-tions,pure calcifications were more detected in the HER-2+ group (P=0.000),and pure masses were more detected in the HER-2-group (P<0.001).The HER-2+ group was more likely showed as a lobulated mass (P<0.001),and with spiculated margin (P=0.000). However,the HER-2- group was more likely showed as a round mass (P=0.014),and with smooth margin (P=0.000).The cal-cifications of HER-2+ group were more likely showed as malignancy calcifications (P=0.000).Conclusion HER-2 overexpression breast cancer with ER- has some mammographic and clinical features,which is helpful for individual diagnosis and treatment.
