Therapeutic effect of atorvastatin combined clopidogrel on patients with angina pectoris and their prog-nosis
10.3969/j.issn.1008-0074.2017.01.22
- VernacularTitle:阿托伐他汀联合氯吡格雷治疗不稳定型心绞痛患者的效果及预后
- Author:
Xiaohong WANG
- Keywords:
Angina,unstable;
C-reactive protein Atorvastatin;
Clopidogrel
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(1):82-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze therapeutic effect of atorvastatin combined clopidogrel on patients with unstable an‐gina pectoris (UAP) and its influence on prognosis .Methods :A total of 215 UAP patients were randomly divided in‐to atorvastatin group (n=106 ,received atorvastatin based on routine treatment ) and combined treatment group (n=109 ,received atorvastatin combined clopidogrel based on routine treatment ) .Therapeutic effect ,levels of serum high sensitive C reactive protein (hsCRP) ,blood lipids and interleukin (IL)‐6 etc .were compared between two groups .Results:Total effective rate of combined treatment group was significantly higher than that of atorvastatin group (94.5% vs .76.4% ,P<0.01) .Compared with before treatment ,there were significant reductions in levels of hsCRP ,IL‐6 and total cholesterol (TC) in both groups after treatment ,P<0.01 all;compared with atorvastatin group ,there were significant reductions in levels of hsCRP [ (5.35 ± 1.37) mg/L vs .(3.36 ± 1.25) mg/L] ,IL‐6 [ (17.36 ± 4.58) pg/ml vs .(12.28 ± 3.24) pg/ml] ,TC [ (7.69 ± 1.20) mmol/L vs .(4.35 ± 1.20) mmol/L] and TG [ (3.35 ± 1.02) mmol/L vs .(1.29 ± 0.25) mmol/L] in combined treatment group , P<0.01 all .Total inci‐dence rate of adverse cardiac events in combined treatment group was significantly lower than that of atorvastatin group (3.7% vs .16.0% ,P=0.002) .Conclusion:Atorvastatin combined clopidogrel cansignificantly enhance ther‐apeutic effect , effectively inhibit inflammation ,reduce incidence rate of adverse cardiac events in patients with un‐stable angina pectoris .