Therapeutic effect of Tanshinone IIA-sulfonic sodium on CHD patients and its influence on hemorheolo-gy,cytokines and blood lipid levels
10.3969/j.issn.1008-0074.2017.01.28
- VernacularTitle:丹参酮 IIA 磺酸钠治疗冠心病的疗效及对血液流变学、细胞因子和血脂水平的影响
- Author:
Tiantian CAO
;
Haili XU
;
Yan HE
- Keywords:
Tanshinone;
Coronary disease;
Angina Pectoris
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(1):104-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore therapeutic effect of Tanshinone IIA‐sulfonic sodium on patients with coronary heart disease (CHD) and its influence on hemorheology ,cytokines and blood lipid levels .Methods :A total of 98 CHD patients treated in our hospital were selected .According to random number table ,they were randomly and e‐qually divided into routine treatment group and Tanshinone IIA group (received intravenous drip of Tanshinone IIA sulfonate sodium based on routine treatment group ) . Therapeutic effect , hemorheologic indexes , cytokines and blood lipid levels before and after treatment ,and adverse drug reaction were compared between two groups .Re‐sults:Compared with routine treatment group , there was significant rise in total effective rate (73.47% vs . 93.88% ) in tanshinone IIA group ,P=0.003. Compared with before treatment ,after treatment ,there were signif‐icant improvement in levels of blood lipid ,blood viscosity ,and cytokines in Tanshinone IIA group , P< 0.01 all . Compared with routine treatment group after treatment ,there was significant rise in HDL‐C level [ (1.32 ± 0.20) mmol/L vs .(1.74 ± 0.26) mmol/L] ,significant reductions in levels of LDL‐C [(3.27 ± 0.50) mmol/L vs .(2.03 ± 0.29) mmol/L] ,TG [ (2.69 ± 0.48) mmol/L vs .(1.43 ± 0.30) mmol/L] and TC [ (6.89 ± 1.02) mmol/L vs . (4.29 ± 0.71) mmol/L];significant reductions in plasma viscosity [ (2.59 ± 0.61) mPa s vs .(1.45 ± 0.32) mPa s] , whole blood viscosity [(4.63 ± 1.37) mPa s vs .(2.97 ± 0.85) mPa s] ,platelet adhesion rate [(36.73 ± 4.51)% vs . (30.74 ± 3.37)% ] ,levels of Fg [(4.12 ± 0.99) g/L vs .(3.04 ± 0.78) g/L] ,ICAM‐1 [(106.79 ± 30.15) pg/ml vs . (78.43 ± 14.52) pg/ml] ,CRP [(19.98 ± 3.89) mg/L vs .(10.82 ± 2.19) mg/L] and TNF‐α[(27.91 ± 4.78) pmol/L vs .(17.84 ± 3.56) pmol/L] in Tanshinone IIA group ,P<0.01 all .No severe adverse reaction was found in two groups .Conclusion:Tanshinone IIA sulfonate sodium possesses significant therapeutic effect on CHD patients .It can significantly improve patient′s hemorheology ,blood lipid and reduce cytokine levels ,and it′s safe and reliable .
