Study of acute lymphoblastic leukemia and acute myeloid leukemia gene mutation in children
10.3760/cma.j.issn.2095-428X.2017.03.003
- VernacularTitle:儿童急性淋巴细胞及急性髓系白血病基因突变研究进展
- Author:
Xin TIAN
;
Yali WANG
;
Jingpei CHEN
;
Xiaowen LIU
;
Jing SUN
;
Chunhui YANG
- Keywords:
Child;
Acute leukemia;
Chromosome mutation;
Fusion gene
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(3):172-176
- CountryChina
- Language:Chinese
-
Abstract:
Acute leukemia is the most common malignant tumor in children in our country.Its pathogenesis includes transformation of proto oncogene,tumor suppressor gene distortion,inhibition of apoptosis etc..Under the action of carcinogenic factors,chromosome mutation,deletion,rearrangement or gene amplification can lead to the structural variation of proto oncogenes and tumor suppressor genes,resulting in a new fusion gene.Some of these genes are tran-scription factors regulating cell proliferation,differentiation,aging and death,when the gene is mutated,directly affect the downstream signaling pathways,leading to cell proliferation,apoptosis and enhanced (or)differentiation disorders, leading to leukemia.In recent years,with the development of gene sequencing technology,more and more leukemia prognostic genes have been displayed in public view and applied in clinical treatment and prognosis,relapse,etc..
