Altered expression and clinical significance of plasma circulating microRNA-23b in patients with myasthnia gravis

VernacularTitle:重症肌无力患者血浆中循环微小核糖核酸-23 b的检测及其临床意义
Author: Xueling ZHOU ; Jianjian WANG ; Huixue ZHANG ; Lihua WANG
Keywords: Myasthenia gravis; Plasma; Circulating microRNA; MicroRNA-23b
From: Chinese Journal of Neurology 2017;50(3):213-217
CountryChina
Language:Chinese
Abstract: Objective To evaluate the expression and clinical significance of plasma circulating microRNA-23b in patients with myasthenia gravis (MG).Methods Plasma samples from 32 MG patients and 32 healthy people were collected in the Second Affiliated Hospital of Harbin Medical University from October 2015 to August 2016. Expression of microRNA-23b was detected by quantitative reverse transcription polymerase chain reaction .The relationship among microRNA-23b expression level, clinical features and quantitative myasthenia gravis score ( QMG ) was analyzed. Results The expression of circulating microRNA-23b in plasma was significantly higher in MG patients (4.587 (3.654, 5.423)) compared with control group (2.889 (1.968, 4.027), Z=-4.169, P<0.01), meanwhile it was positively related to QMG (r=0.661,P<0.01).But the expression of circulating microRNA-23b had no statistically significant difference in MG subgroups .Conclusion Plasma circulating microRNA-23b is highly expressed in MG and has positive correlation with MG severity .