Correlation between carotid lesion severity detected by ultrasound and PAPP-A expression in ACS pa-tients
10.3969/j.issn.1008-0074.2017.01.06
- VernacularTitle:急性冠脉综合征超声颈动脉粥样硬化病变程度与妊娠相关蛋白A表达的相关性
- Author:
Daobing JI
;
Li SHANG
;
Xintao ZHOU
;
Dongfeng LI
;
Xiaoqiang CHEN
;
Caixia TIAN
- Keywords:
Acute coronary syndrome;
Ultrasonography;
Pregnancy proteins
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between carotid lesion severity detected by ultrasound and pregnancy associated plasma protein A (PAPP‐A) expression in patients with acute coronary syndrome (ACS) .Methods :A to‐tal of 78 ACS patients hospitalized in our hospital from Feb 2012 to May 2015 were regarded as ACS group ,mean‐while ,another 78 healthy subjects were enrolled as healthy control group .Correlation between carotid lesion severi‐ty detected by ultrasound and PAPP‐A expression was analyzed . Results:Compared with healthy control group , there were significant rise in serum PAPP‐A concentration [ (0.97 ± 0.32) mg/L vs .(1.56 ± 0.19) mg/L] ,carotid intima‐media thickness [IMT ,(0.84 ± 0.13) mm vs .(1.28 ± 0.16) mm] and Crouse plaque score [ (2.98 ± 1.92) scores vs .(8.24 ± 1.13) scores] in ACS group ,P<0.01 all .Linear correlation analysis indicated that serum PAPP‐A concentration was significant positively correlated with Crouse plaque score and IMT ( r= 0.342、0.243 , P<0.05 all) .Multi‐factor gradual linear regression analysis indicated that carotid Crouse plaque score and IMT were in‐dependent risk factors for PAPP‐A (partial regression coefficient=1.932 ,17.722 ,P<0.01 both) .Conclusion:Ca‐rotid ultrasound Crouse plaque score ,IMT are significantly positively correlated with PAPP‐A expression ,which can indirectly reflect coronary artery disease severity in ACS patients ,it is worth extending .
