Effect of thalidomide combined with gefitinib on quality of life andsurvival in advanced non-small cell lung cancer
10.3969/j.issn.1005-1678.2017.01.054
- VernacularTitle:沙利度胺联合吉非替尼对晚期非小细胞肺癌患者生存质量及生存期的影响
- Author:
Fang LIU
;
Tingyu TANG
;
Jianzong DU
;
Guangyue QIN
- Keywords:
thalidomide;
gefitinib;
non-small cell lung cancer;
prognosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):185-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of thalidomide combined with targeted therapy of gefitinib on quality of life and survival in patients with advanced non-small cell lung cancer. Methods 90 cases with non-small cell lung cancer were selected in our hospital, according to the treatment were divided into observation group and control group, the observation group were treated by thalidomide combined with gefitinib treatment, patients in the control group received only gefitinib treatment, treatment effects was compared between the two groups, the remission rate, quality of life and survival were compared between two groups of patients. Results The effective rate of the observation group patients was 55.6%, compared with 33.3% in the control group, the difference was statistically significant (P<0.05), the life quality of the observation group of general health (general health, GH), physical functioning (PF), role –physical (RP), role-emotional (RE), mental health (MH), social functioning (SF), bodily pain (BP) and vitality (VT) were significantly better than the control group (P<0.05), there was no significant difference in 1, 2, 3, 4 years survival rate between two groups, while 5 years survival rate in observation group was higher than the control group(P<0.05). Conclusion Thalidomide combined with gefitinib targeted therapy is helpful to improve the quality of life and 5 years survival rate of non-small cell lung cancer.
