Effect of dexamethasone combined with clomiphene on serum sex hormone levels in polycystic ovary syndrome
10.3969/j.issn.1005-1678.2017.01.070
- VernacularTitle:地塞米松联合氯米芬治疗多囊卵巢综合症对患者血清性激素水平的影响
- Author:
Meifeng XU
;
Qing WEI
;
Ting HE
- Keywords:
dexamethasone;
clomiphene;
combine;
polycystic ovary syndrome;
hormone
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):235-238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of dexamethasone combined with clomiphene on serum sex hormone levels in patients with polycystic ovary syndrome. Methods 80 pregnancies with polycystic ovary syndrome treated in our hospital from January 2013 to December 2015 were selected and they were randomly divided into observation group and control group with 40 cases in each group. The observation group was given dexamethasone combined with clomiphene, while the control group was given simple clomiphene. Compared the curative effect and the change of the levels of progesterone and estradiol before and after treatment for three months. Results After treatment, the total effective rate of the observation group was 95.00%, higher than the total effective rate of the control group was 72.50%, the difference was statistically significant (P<0.05), compared the levels of progesterone(P), estradiol(E2), luteinizing hormone(LH) and LH/FSH in the observation group and the control group, the difference was statistically significant (P<0.05), after treatment, both levels were higher than before treatment. The total ovulation rate of the observation group was 90.00%, higher than the total ovulation rate of the control group was 72.50%, the difference was statistically significant (P<0.05). The level of progesterone and estradiol in serum of polycystic ovary syndrome treated by dexamethasone combined with clomiphene had a obvious positive correlation (r=0.746, 0.812, 0.731 and 0.796, P<0.05). Conclusion Dexamethasone combined with clomiphene treatment of polycystic ovary syndrome than using only clomiphene treatment is good, which can also improve serum hormone levels in patients, effectively improve the patient's endocrine abnormalities.
