Preparation and Properties Study of Albendazole Nanoliposomes Freeze-dried Powder
10.6039/j.issn.1001-0408.2017.07.30
- VernacularTitle:阿苯达唑纳米脂质体冻干粉的制备及性质考察
- Author:
Bei CHEN
;
Chunyan CHEN
;
Huijing GAO
;
Jianhua WANG
;
Jun ZHAO
- Keywords:
Albendazole;
Nanoliposomes;
Freeze-dried powder;
Particle size;
Encapsulation efficiency;
Stability;
Orthogonal test
- From:
China Pharmacy
2017;28(7):967-970
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare the Albendazole nanoliposomes freeze-dried power and study its properties. METHODS:Freeze-drying method was conducted to prepare Albendazole nanoliposomes freeze-dried power,using the particle size,encapsula-tion efficiency,appearance,redispersibility as indexes,single factor test was combined with orthogonal test to screen freeze-drying preparation technology. The morphological changes,particle size,Zeta potential,moisture content,12 months stability at 4 ℃ be-fore and after freeze-drying were detected. RESULTS:Plus a total content of freeze-dried protective agent was 10%,the ratio of glucose-trehalose-mannitol was 1.0:1.0:3.0,using quick-freeze,pre-freezing 18 h in -35 ℃ refrigerator,dry-freezing 48 h to ob-tain freeze-dried powder. Compared with before freeze-drying,the freeze-dried liposomal morphology had no obvious changes, showing clear phospholipid bilayer membrane structure;the particle sizes before and after freeze-drying were (208.63 ± 1.04) nm and (223.04 ± 2.02) nm,Zeta potentials were (-15.6 ± 0.04) mV and (-19.4 ± 0.06) mV,encapsulation efficiencies were (94.62±0.49)%and(91.10±0.46)%(n=3),respectively. Compared with liposomes,liposomes freeze-dried power had good sta-bility in 12 months at 4 ℃. CONCLUSIONS:Albendazole nanoliposomes freeze-dried power is prepared successfully,its stability is superior to albendazole nanoliposomes,and the freeze-drying technology is feasible.
