Progress of predicting response to immunosuppressive therapy in aplastic anemia
10.3760/cma.j.issn.2095-428X.2017.03.017
- VernacularTitle:免疫抑制治疗再生障碍性贫血疗效预测指标研究进展
- Author:
Shuanglong LU
;
Xiaotian XIE
- Keywords:
Aplastic anemia;
Immunosuppressive therapy;
Prognosis factors
- From:
Chinese Journal of Applied Clinical Pediatrics
2017;32(3):235-237
- CountryChina
- Language:Chinese
-
Abstract:
Aplastic anemia is a severe hematological disease characterized by bone marrow failure and pancyto-penia.Immunosuppressive therapy(IST)with antithymocyte globulin(ATG)and cyclosporine A(CSA)is the first -line treatment for patients who lack an HLA -matched sibling.One third of the patients has no response to IST and the high risk of ATG -related adverse effects may lead to ATG -related death.So it is necessary to explore the predictive marker of response to IST.A defined predictive marker may make the selection of treatment more reasonable and further improve the long -term efficacy.The relevant literatures were analyzed and summarized in recent years,in order to pro-vide a reference for clinical treatment and a baseline for prospective studies.
