Pathology of Thrombotic Microangiopathy.
- Author:
Mee Young SOL
1
Author Information
1. Department of Pathology, Pusan National Universtiy Yangsan Hospital, Kyoungsangnam-do, Korea. mysol@pusan.ac.kr
- Publication Type:Review
- Keywords:
Thrombotic microangiopathy;
Renal biopsy
- MeSH:
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis;
Antibodies;
Antibodies, Antineutrophil Cytoplasmic;
Antiphospholipid Syndrome;
Autoimmune Diseases;
Biopsy;
Blood Platelets;
Drug Toxicity;
Eclampsia;
Female;
Humans;
Hypertension, Malignant;
Kidney;
Pre-Eclampsia;
Pregnancy;
Thrombosis;
Thrombotic Microangiopathies;
Transplants
- From:Journal of the Korean Society of Pediatric Nephrology
2013;17(1):6-12
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thrombotic microangiopathy (TMA) is a microvascular thrombotic lesion caused by endothelial injury and subsequent formation of platelet rich thrombus. TMA is first described as a classical pathologic feature of HUS/TTP. Renal biopsy finding of TMA represents kidney involvement of HUS/TTP as well as other diseases such as malignant hypertension, drug toxicity, eclampsia, pre-eclampsia, and several systemic infections. Autoimmune diseases and transplant kidney sometime also have TMA. It is needed to consider a complete autoimmune work-up of patients presenting with TMA including tests for ANA, ANCA, and ADAMTS13 inhibitory antibodies, because there are several reports of association with TMA in patients of SLE, anti-phospholipid syndrome, and ANCA-associated vasculitis.
