Experimental Study of Therapeutic Effect of Liyanling Granules on Chronic Pharyngitis in Rats
- VernacularTitle:利咽灵对慢性咽炎大鼠治疗作用的实验研究
- Author:
Ming YANG
;
Hui HE
;
Dewei YU
;
Ming YANG
;
Guofang GUAN
- Keywords:
Liyanling granules;
Chronic pharyngitis;
Anti-inflammatory;
Hemorheology
- From:
China Pharmacist
2017;20(3):442-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the therapeutic effect of Liyanling granules on chronic pharyngitis. Methods:The chronic pharyn-gitis rat models were established, and administered orally for 7 days. The influence of Liyanling granules on the pathology of pharyngeal tissue and the contents of PGE2 , IL-1β and TNF-α were observed. The blood was withdrawn to detect the whole blood viscosity and plasma viscosity, and the anti-inflammatory effects were observed in two kinds of rat models:foot pad swelling induced by carrageenin and agar-induced chronic granuloma. Results:Liyanling granule could significantly decrease the levels of PGE2 , IL-1βand TNF-α( P<0. 05 or P<0. 01) and the viscosity of blood and plasma(P<0. 05 or P<0. 01), improve the pathological morphology of rat pharynge-al tissues(P<0. 05 or P<0. 01), inhibit the swelling of foot pad induced by carrageenin and the granuloma induced by agar in rats(P<0. 05 or P<0. 01). Conclusion:Liyanling granules has a certain therapeutic effect on chronic pharyngitis in rats, and the mecha-nism may be related with the inhibition of inflammatory cytokines PGE2 ,IL-1β and TNF-α and the improvement of blood rheology.
